The 6 ESID warning signs for ADULT primary immunodeficiency diseases

1. Four or more infections requiring antibiotics within one year (otitis, bronchitis, sinusitis, pneumonia)
2. Recurring infections or infection requiring prolonged antibiotic therapy
3. Two or more severe bacterial infections (osteomyelitis, meningitis, septicemia, cellulitis)
4. Two or more radiologically proven pneumonia within 3 years
5. Infection with unusual localization or unusual pathogen
6. PID in the family