Differential Diagnosis of Hypogammaglobulinemia

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Drug Induced

Antimalarial agents

Captopril

Carbamazepine

Glucocorticoids

Fenclofenac

Gold salts

Penicillamine

Phenytoin

Sulfasalazine

Genetic Disorders

Ataxia Telangiectasia

Autosomal forms of SCID

Hyper IgM Immunodeficiency

Transcobalamin II deficiency and hypogammaglobulinemia

X-linked agammaglobulinemia

X-linked lymphoproliferative disorder (EBV associated)

X-linked SCID

Some metabolic disorders

Chromosomal Anomalies

Chromosome 18q- Syndrome

Monosomy 22

Trisomy 8

Trisomy 21

Infectious Diseases

HIV

Congenital Rubella

Congenital infection with CMV

Congenital infection with Toxoplasma gondii

Epstein-Barr Virus

Malignancy

Chronic Lymphocytic Leukemia

Immunodeficiency with Thymoma

Non Hodgkin's lymphoma

B cell malignancy

Systemic Disorders

Immunodeficiency caused by hypercatabolism of immunoglobulin

Immunodeficiency caused by excessive loss of immunoglobulins (nephrosis, severe burns, lymphangiectasia, severe diarrhea)