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Recruiting Senior Postdoctoral Scientist/Deputy Group Leader (Immunology)

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Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Closing date is 31 January 2019 (call will remain open until the position is filled).

Senior Postdoctoral Scientist/Deputy Group Leader will join the research group of Assoc. Prof. Dr. Kaan Boztug at the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD) in Vienna, Austria. Together with the Lab Head and Director of LBI-RUD, Kaan Boztug, you will be leading defined projects focusing on deciphering the molecular basis of human immune dysregulation, and contribute to coordination and advancement of the group’s research projects.

The successful candidate will work within the framework of the newly ERC-funded “iDysChart” project. iDysChart – Charting key molecules and mechanisms of human immune Dysregulation Failure/disorders of the immune system to protect itself can result in autoimmunity and autoinflammation as observed in many human diseases. This interesting project aims at i) identifying novel monogenic causes of autoimmune/autoinflammatory diseases, enabling elucidation of fundamental mechanisms, ii) creating a network-level understanding of molecular pathways of immune dysregulation and iii) employing chemical and genetic screens to complement human disease gene discovery in predicting the core human immune dysregulome and investigating potential avenues for therapeutic modulation.
Previous projects of our working group have already led to the identification of novel disease-causing genes in patients with autoimmune disorders (van Rijn et al., Gastroenterology 2018; Ozen et al., NEJM 2017; Salzer et al., Nat Immunol 2016; Dobbs et al., NEJM 2015).

The iDysChart project will particularly focus on deciphering key principles of human autoimmunity and autoinflammation by studying model diseases including very early-onset IBD, monogenic autoimmune disorders, such as systemic lupus erythematodes (SLE), and systemic autoinflammatory disorders.