The European Primary Immunodeficiencies (PIDs) Consensus Conference in Langen (2006) outlined the need for quality assurance for assays to measure specific antibodies to common pathogens and immunization antigens. In order to make a diagnosis of primary antibody failure, it is important to show that a patient is unable to make antibodies to pathogens; this may be demonstrated using either common exposure antigens or those used for immunization. Streptococcus pneumoniae, a common gram positive bacterium, is one such pathogen that is estimated by the WHO to be responsible for over one million acute deaths worldwide. This includes patients with primary immune deficiencies, who are particularly susceptible to infections caused by encapsulated bacteria.
In July 2007, the XLT working group has initiated a survey on patients with X-linked Thrombocytopenia, a mild subtype of Wiskott-Aldrich syndrome. This survey can be filled in by ESID Centres in the ESID Online Database inside the new XLT subregistry.
Centres which are not participating in the ESID Database yet can either join the database by writing an email to or they can contact the XLT working group by filling in the contact form below.
Young Researcher Corner - December 2011, by Immacolata Brigida
YOUNG RESEARCHERS' CORNER Spring 2011, by Sara Ciullini Mannurita